Atom economy (atom efficiency) is the conversion efficiency of a chemical process in terms of all atoms involved and the desired products produced. Atom economy is an important concept of green chemistry philosophy, and one of the most widely used metrics for measuring the "greenness" of a process or synthesis.
Atom economy can be written as:
By the conservation of mass, the total molecular mass of the reactants is the same as the total molecular mass of the products. In an ideal chemical process, the amount of starting materials or reactants equals the amount of all products generated and no atom is wasted. However, in some processes, some of the consumed reactant atoms do not become part of the intended products. This can be a concern for raw materials that have a high cost or due to economic and environmental costs of disposal of the waste.
Atom economy is a different concern than chemical yield, because a high-yielding process can still result in substantial byproducts. Examples include the Cannizzaro reaction, where approximately 50% of the reactant aldehyde becomes the other oxidation state of the target, the Wittig reaction, where high-mass phosphorus reagents are used but ultimately become waste, and the Gabriel synthesis, which produces a stoichiometric quantity of phthalic acid
If the desired product has an enantiomer the reaction needs to be sufficiently stereoselective even when atom economy is 100%. A Diels-Alder reaction is an example of a potentially very atom efficient reaction that also can be chemo-, regio-, diastereo- and enantioselective. Catalytic hydrogenation comes the closest to being an ideal reaction that is extensively practiced both industrially and academically.
Atom economy can also be adjusted if a pendant group is recoverable, for example Evans auxiliary groups. However, if this can be avoided it is more desirable, as recovery processes will never be 100%. Atom economy can be improved upon by careful selection of starting materials and a catalyst system.
Poor atom economy is common in fine chemicals or pharmaceuticals synthesis, and especially in research, where the aim to readily and reliably produce a wide range of complex compounds leads to the use of versatile and dependable, but poorly atom-economical reactions. For example, synthesis of an alcohol is readily accomplished by reduction of an ester with lithium aluminium hydride, but the reaction necessarily produces a voluminous floc of aluminum salts, which have to be separated from the product alcohol and disposed of. The cost of such hazardous material disposal can be considerable. Catalytic hydrogenolysis of an ester is the analogous reaction with a high atom economy, but it requires catalyst optimization, is a much slower reaction and is not applicable universally.
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Creating reactions utilizing atom economy
It is fundamental in chemical reactions of the form A+B-> C+D that two products are necessarily generated though product C may have been the desired one. That being the case, D is considered a byproduct. As it is a significant goal of green chemistry to maximize the efficiency of the reactants and minimize the production of waste, D must either be found to have use, be eliminated or be as insignificant and innocuous as possible. With the new equation of the form A+B->C, the first step in making chemical manufacturing more efficient is the use of reactions that resemble simple addition reactions with the only other additions being catalytic materials.
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References
Source of article : Wikipedia
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